SARS-CoV-2 pandemic as a model to assess the relationship between intercurrent viral infections and disease activity in Multiple Sclerosis: a propensity score matched case-control study
SYNOPSIS AND RESULTS
The association between intercurrent viral respiratory infections and exacerbations of Multiple Sclerosis (MS) disease activity has been for many years an open question. This is a propensity score matched, case-control, observational study in a single-center cohort of patients with relapsing-remitting MS (RRMS) who tested positive for SARS-CoV-2 in 2020-2022, with the aim to evaluate if the SARS-CoV-2 infection influences the shortterm risk of clinical/MRI disease activity. All incident cases of SARS-CoV-2 infection observed in RRMS patients followed at the MS Center of the AOU Città della Salute e della Scienza di Torino in the period March 2020 - March 2022 will be included in the study. Controls will be selected from the total population of MS patients followed at the MS Center of the AOU Città della Salute e della Scienza di Torino, using a 1:1 propensity score matching for age, EDSS, sex and DMT. The reference period for controls will be 2019, prior to the pandemic, in order to exclude the possibility of unidentified SARS-CoV-2 infections. In order to evaluate the influence of the SARS-CoV2 infection on the risk of short-term clinical/MRI disease activity, we will assess the differences in the EDA-3 status, presence/absence of relapses, presence/absence of MRI disease activity,presence/absence of confirmed disability worsening between cases and controls between cases in the 6 months following the SARS-CoV-2 infection, and controls in a similar 6 months reference period in 2019.
Fondazione Italiana Sclerosi Multipla – FISM – Ente del Terzo Settore/ETS e, in forma abbreviata, FISM ETS. Iscrizione al RUNTS Rep. N° 89695 - Fondazione con Riconoscimento di Personalità Giuridica - C.F. 95051730109
SARS-CoV-2 pandemic as a model to assess the relationship between intercurrent viral infections and disease activity in Multiple Sclerosis: a propensity score matched case-control study
The association between intercurrent viral respiratory infections and exacerbations of Multiple Sclerosis (MS) disease activity has been for many years an open question. This is a propensity score matched, case-control, observational study in a single-center cohort of patients with relapsing-remitting MS (RRMS) who tested positive for SARS-CoV-2 in 2020-2022, with the aim to evaluate if the SARS-CoV-2 infection influences the shortterm risk of clinical/MRI disease activity. All incident cases of SARS-CoV-2 infection observed in RRMS patients followed at the MS Center of the AOU Città della Salute e della Scienza di Torino in the period March 2020 - March 2022 will be included in the study. Controls will be selected from the total population of MS patients followed at the MS Center of the AOU Città della Salute e della Scienza di Torino, using a 1:1 propensity score matching for age, EDSS, sex and DMT. The reference period for controls will be 2019, prior to the pandemic, in order to exclude the possibility of unidentified SARS-CoV-2 infections. In order to evaluate the influence of the SARS-CoV2 infection on the risk of short-term clinical/MRI disease activity, we will assess the differences in the EDA-3 status, presence/absence of relapses, presence/absence of MRI disease activity,presence/absence of confirmed disability worsening between cases and controls between cases in the 6 months following the SARS-CoV-2 infection, and controls in a similar 6 months reference period in 2019.
Monocentrico: TO099
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